Opportunity Information: Apply for RFA AT 19 004
The HEAL Initiative PRISM funding opportunity (RFA-AT-19-004) is a National Institutes of Health (NIH) cooperative agreement designed to support large, real-world studies that improve pain management and reduce reliance on opioid medications. It focuses on pragmatic clinical trials and implementation science approaches that can be carried out efficiently at scale, with an emphasis on interventions that can work within routine health care delivery rather than under highly controlled, ideal research conditions. Clinical trials are optional under this announcement, meaning applicants may propose either pragmatic trial designs or implementation-focused studies depending on what best fits the research question and the maturity of the intervention.
The award mechanism uses a phased UG3/UH3 structure. Applicants submit a single, combined application that includes both phases. The UG3 phase provides up to one year of support for a milestone-driven planning period, where investigators are expected to finalize protocols, confirm feasibility, establish operational partnerships, and demonstrate readiness to launch. If the UG3 milestones are met, the project can transition to the UH3 phase, which supports the full implementation and execution of the study. This structure is meant to reduce risk and ensure that only projects with clear feasibility and strong operational footing move into the more resource-intensive implementation stage.
A central requirement is that the intervention being evaluated must be embedded directly into real-world health care delivery settings. Rather than testing something in isolation, studies must be integrated into clinical workflows and systems, such as electronic health record-supported decision tools, care pathway redesigns, stepped-care models, provider or patient-facing behavioral interventions deployed through the health system, or other system-level changes. Applicants may propose to scale interventions that already have evidence of efficacy, or they may focus on implementing health care system changes that improve adherence to evidence-based pain management and opioid prescribing guidelines. The overarching goal is to identify practical, system-level methods that help patients receive effective pain care while reducing unnecessary or high-risk opioid exposure.
The FOA also requires that studies be conducted across two or more health care systems, reinforcing the intent to generate findings that are generalizable and transferable beyond a single institution. In addition, projects must be conducted as part of the NIH Health Care Systems Research Collaboratory, a NIH Common Fund-supported program aimed at advancing best practices for embedded pragmatic research. Awardees will work closely with the Collaboratory Coordinating Center (CCC), which provides national leadership and hands-on technical expertise in conducting research in partnership with health care systems. After awards are made, NIH and the CCC support teams in refining plans and accelerating execution so that trials and implementation studies can be launched and completed with high impact and operational realism.
From an administrative standpoint, this opportunity is categorized as a discretionary cooperative agreement, which signals substantial NIH involvement during the project compared to a traditional grant. The activity category is listed broadly under education, health, income security, and social services, and multiple CFDA numbers are associated with the announcement, reflecting participation across NIH institutes and programs. The original closing date for the listed cycle was February 8, 2019, and the opportunity record indicates an award ceiling of $500,000, though actual budgets in cooperative embedded research often depend on scope, number of sites, and the final negotiated project plan under the UG3/UH3 milestones.
Eligibility is broad and includes state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; and other eligible entities. The FOA also explicitly highlights a variety of institution types as eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, it clearly restricts foreign participation: non-U.S. (non-domestic) entities are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.
In practical terms, NIH is looking for proposals that can change how pain is managed at the health system level, produce outcomes that matter to patients and clinicians, and demonstrate scalable approaches that reduce opioid prescribing when opioids are not necessary or are being used in ways that increase risk. The combination of a milestone-based planning year, required multi-system participation, and integration into the NIH Collaboratory framework is intended to ensure these projects are not only scientifically sound but also operationally realistic, rapidly executable, and positioned to inform policy and practice across diverse health care settings.Apply for RFA AT 19 004
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "HEAL Initiative: Pragmatic and Implementation Studies for the Management of Pain to Reduce Opioid Prescribing (PRISM) (UG3/UH3, Clinical Trials Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.213, 93.273, 93.307, 93.350, 93.361, 93.393, 93.846, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2018-12-10.
- Applicants must submit their applications by 2019-02-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| HEAL Initiative: Tissue Chips to Model Nociception, Addiction, and Overdose (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA TR 19 003 Funding Number: RFA TR 19 003 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| HEAL Initiative: Preventing Opioid Use Disorder in Older Adolescents and Young Adults (ages 1630) (UG3/UH3 Clinical Trial Required) Apply for RFA DA 19 035 Funding Number: RFA DA 19 035 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Behavioral Research to Improve MAT: Behavioral and Social Interventions to Improve Adherence to Medication Assisted Treatment for Opioid Use Disorders (R61/R33 Clinical Trial Optional) Apply for RFA AT 19 006 Funding Number: RFA AT 19 006 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required) Apply for PA 19 127 Funding Number: PA 19 127 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Not Allowed) Apply for PA 19 124 Funding Number: PA 19 124 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) Apply for PA 19 126 Funding Number: PA 19 126 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Required) Apply for PA 19 129 Funding Number: PA 19 129 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required) Apply for PAR 19 135 Funding Number: PAR 19 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R21-Clinical Trial Not Allowed) Apply for PAR 19 163 Funding Number: PAR 19 163 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| HIV/AIDS Clinical Trials Networks Laboratory Centers (UM1 Clinical Trial Required) Apply for RFA AI 19 001 Funding Number: RFA AI 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV Prevention Clinical Trials Network Leadership and Operations Center (UM1 Clinical Trial Required) Apply for RFA AI 19 005 Funding Number: RFA AI 19 005 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV/AIDS Clinical Trials Networks Statistical and Data Management Centers (SDMC) (UM1 Clinical Trial Required) Apply for RFA AI 19 002 Funding Number: RFA AI 19 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (R01 Clinical Trial Optional) Apply for RFA AI 19 022 Funding Number: RFA AI 19 022 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $350,000 |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (U01 Clinical Trial Optional) Apply for RFA AI 19 023 Funding Number: RFA AI 19 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $250,000 |
| BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 135 Funding Number: RFA MH 20 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Secondary Analysis and Archiving of BRAIN Initiative Data (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 120 Funding Number: RFA MH 20 120 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Brain Initiative: Research to Develop and Validate Advanced Human Cell-Based Assays To Model Brain Structure and Function (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 140 Funding Number: RFA MH 20 140 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| "Clinical Trials" on a Chip: Tissue Chips to Inform Clinical Trial Design and Implementation in Precision Medicine (UG3/UH3 - Clinical Trial Not Allowed) Apply for RFA TR 19 014 Funding Number: RFA TR 19 014 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| BRAIN Initiative: Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (R01 Clinical Trial Not Allowed) Apply for RFA EB 19 001 Funding Number: RFA EB 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| BRAIN Initiative: Development of Next Generation Human Brain Imaging Tools and Technologies (U01 Clinical Trial not allowed) Apply for RFA EB 19 002 Funding Number: RFA EB 19 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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