Opportunity Information: Apply for RFA HS 23 001
The AHRQ and PCORI Learning Health System Embedded Scientist Training and Research Centers (P30), funding opportunity number RFA-HS-23-001 (CFDA 93.226), is a discretionary grant program run by the Agency for Health Care Research and Quality in partnership with the Patient-Centered Outcomes Research Institute. The core purpose is to fund institutions that can stand up dedicated centers, called LHS E-STaR Centers, that train and support scientists who are embedded in real-world health system settings and who can produce research that helps move the U.S. toward a more integrated learning health system. In practical terms, the opportunity is aimed at building the people, partnerships, and institutional infrastructure needed so that health systems can learn from routine care, generate evidence more quickly, and translate findings into operational improvements that patients and communities actually experience.
The centers supported under this program are expected to do several things at once, rather than focusing only on training or only on research. First, they must create or strengthen institutional models and infrastructure for learning health system work, with a strong emphasis on training in comparative effectiveness research (CER) and patient-centered outcomes research (PCOR). That means preparing investigators to evaluate which interventions, workflows, or care strategies work best for which patients under real-world conditions, not just in controlled settings. Second, the program explicitly emphasizes workforce diversity, so the centers are expected to recruit, train, and advance scientists from backgrounds that are historically underrepresented in health research and in health system leadership. Third, the centers must deepen partnerships with community partners, health systems, and other stakeholders, reflecting the learning health system idea that evidence generation and implementation should be co-produced with the people and organizations affected by the results. Finally, the centers are expected to conduct patient-centered clinical comparative effectiveness research projects that directly target improvements in health system operations, care quality, and health outcomes, so the training environment is anchored in active, applied research rather than classroom learning alone.
Eligibility is broad across U.S.-based organizations and government entities, reflecting the expectation that strong learning health system work often requires cross-sector collaboration. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; and nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education when applying under the nonprofit category). The announcement also calls out additional eligible applicant types such as faith-based or community-based organizations, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), as well as regional organizations and U.S. territories or possessions. At the same time, there are clear restrictions related to foreign involvement: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined in the NIH Grants Policy Statement are not allowed.
From an administrative standpoint, this opportunity was posted on December 22, 2022, with an original application closing date of March 31, 2023. The funding instrument is a grant and the activity category is health. The posted summary does not specify an award ceiling or expected number of awards in the provided fields, so applicants would typically need to consult the full funding announcement for budget limits, project period length, and other detailed requirements.
Overall, the LHS E-STaR Centers program is designed to accelerate learning health system progress by investing in embedded scientist career development and by requiring that training is inseparable from practical, stakeholder-driven CER and PCOR conducted inside functioning health systems. The intended outcome is a stronger, more diverse cadre of investigators who can work side-by-side with operational leaders, clinicians, patients, and communities to generate evidence that is immediately usable and that measurably improves care delivery and outcomes.Apply for RFA HS 23 001
- The Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "AHRQ and PCORI Learning Health System Embedded Scientist Training and Research Centers (P30)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226.
- This funding opportunity was created on 2022-12-22.
- Applicants must submit their applications by 2023-03-31. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others.
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FAQs: AHRQ and PCORI Learning Health System Embedded Scientist Training and Research Centers (P30)
What is this funding opportunity?
This is a discretionary grant program titled the AHRQ and PCORI Learning Health System Embedded Scientist Training and Research Centers (P30). It is offered by the Agency for Health Care Research and Quality (AHRQ) in partnership with the Patient-Centered Outcomes Research Institute (PCORI). The funding opportunity number is RFA-HS-23-001 and the CFDA number listed is 93.226.
What is the core purpose of the program?
The purpose is to fund institutions that can establish dedicated centers (called LHS E-STaR Centers) to train and support scientists who are embedded in real-world health system settings. These embedded scientists are expected to produce research that helps move the U.S. toward a more integrated learning health system, where health systems learn from routine care, generate evidence more quickly, and translate findings into operational improvements experienced by patients and communities.
What are LHS E-STaR Centers?
LHS E-STaR Centers are dedicated institutional centers funded under this program. Their role is to build the people, partnerships, and institutional infrastructure needed to support embedded scientists and applied research inside functioning health systems.
Is the program focused on training, research, or both?
Both. The centers are expected to do several things at once rather than focusing only on training or only on research. Training is intended to be anchored in active, applied work, including patient-centered clinical comparative effectiveness research projects that target improvements in health system operations, care quality, and health outcomes.
What types of research and training does the program emphasize?
The program emphasizes training in comparative effectiveness research (CER) and patient-centered outcomes research (PCOR). In practical terms, this includes preparing investigators to evaluate which interventions, workflows, or care strategies work best for which patients under real-world conditions, not only in controlled research settings.
What does it mean that scientists are "embedded"?
Based on the description provided, embedded scientists are researchers who work within real-world health system settings and collaborate side-by-side with operational leaders, clinicians, patients, communities, and other stakeholders so that evidence generation and implementation are closely tied to day-to-day care delivery and operations.
What are the main expectations for centers funded under this opportunity?
The description lists several core expectations. Centers are expected to (1) create or strengthen institutional models and infrastructure for learning health system work with a strong emphasis on CER and PCOR training, (2) emphasize workforce diversity by recruiting, training, and advancing scientists from backgrounds historically underrepresented in health research and health system leadership, (3) deepen partnerships with community partners, health systems, and other stakeholders, and (4) conduct patient-centered clinical CER projects that directly target improvements in health system operations, care quality, and health outcomes.
How important are partnerships and stakeholder engagement in this program?
They are central to the program design. The opportunity explicitly calls for deepened partnerships with community partners, health systems, and other stakeholders. It reflects a learning health system approach where evidence generation and implementation are co-produced with the people and organizations affected by the results.
Does the opportunity place an emphasis on diversity in the workforce?
Yes. The program explicitly emphasizes workforce diversity, and centers are expected to recruit, train, and advance scientists from backgrounds that have been historically underrepresented in health research and health system leadership.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and government entities. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; and nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education when applying under the nonprofit category).
Are specific institution types called out as eligible?
Yes. The announcement also calls out faith-based or community-based organizations; Hispanic-serving institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs); regional organizations; and U.S. territories or possessions.
Can nonprofits apply, and does 501(c)(3) status matter?
Nonprofit organizations can apply with or without 501(c)(3) status. However, the eligibility language notes a condition: nonprofits are eligible as long as they are not institutions of higher education when applying under the nonprofit category.
Are foreign organizations or foreign components allowed?
No. The restrictions provided state that non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined in the NIH Grants Policy Statement are not allowed.
What is the funding instrument and activity category?
The funding instrument is a grant, and the activity category is health.
When was the opportunity posted and what was the application due date?
The opportunity was posted on December 22, 2022. The original application closing date listed is March 31, 2023.
Is the award ceiling or number of awards provided in the summary?
No. The posted summary fields described do not specify an award ceiling or the expected number of awards. Applicants are typically expected to consult the full funding announcement for budget limits, project period length, and other detailed requirements.
What outcomes is the program trying to achieve?
The intended outcome is a stronger and more diverse cadre of investigators who can work closely with health system operational leaders, clinicians, patients, communities, and other stakeholders to generate evidence that is immediately usable and that measurably improves care delivery and outcomes.
How does this program relate to improving health system operations?
The centers are expected to conduct patient-centered clinical comparative effectiveness research projects that directly target improvements in health system operations, care quality, and health outcomes. The overall approach is meant to help health systems learn from routine care and translate findings into operational improvements experienced by patients and communities.
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