Opportunity Information: Apply for MP CPI 20 002

The Demonstration to Increase Hydroxyurea Prescribing for Children with Sickle Cell Disease Through Provider Incentives (Funding Opportunity Number: MP CPI 20 002) is a discretionary grant program from the U.S. Department of Health and Human Services, specifically the Office of the Assistant Secretary for Health. The purpose of the opportunity is to fund demonstration projects that test whether offering financial incentives to health care providers can increase the rate at which hydroxyurea is prescribed for children with sickle cell disease (SCD), with the broader aim of improving health outcomes and quality of life for pediatric patients living with SCD. A key point in the notice is that, even though the project concept relates to health care payment and provider behavior, the initiative is explicitly not issued or funded by the Centers for Medicare and Medicaid Services (CMS).

Hydroxyurea is a well-established disease-modifying therapy for many children with SCD, and higher prescribing and appropriate use are often associated with fewer painful crises, reduced complications, and fewer hospitalizations. This funding opportunity is structured around the idea that provider-focused financial incentives may help address persistent gaps between clinical guidelines and real-world prescribing patterns. In other words, applicants are expected to design and run a practical demonstration to see whether incentive payments (and the related implementation approach) are feasible in real clinical settings and whether they actually change prescribing behavior in a measurable way.

The program uses the grant funding instrument and falls under the health funding activity category, with CFDA number 93.137. The total potential funding per award is capped at $1,250,000 (the award ceiling), and the agency anticipated making two awards under this notice. The opportunity was posted on July 28, 2020, with an original application deadline of August 27, 2020. Eligibility is listed broadly as "Others," with the expectation that applicants would need to consult the full notice for the specific eligibility clarifications in the "Additional Information on Eligibility" section.

Overall, this opportunity is best understood as a targeted, evidence-generating pilot effort: it is meant to test an incentive-based strategy to improve provider adherence to best practices for pediatric sickle cell care, using hydroxyurea prescribing rates as a concrete quality-related lever. The main deliverable implied by the notice is not only increased prescribing during the project period, but also credible evidence about whether the incentive model is workable, scalable, and associated with meaningful improvements for children with SCD.

  • The Department of Health and Human Services, Office of the Assistant Secretary for Health in the health sector is offering a public funding opportunity titled "Demonstration to Increase Hydroxyurea Prescribing for Children with Sickle Cell Disease Through Provider Incentives" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.137.
  • This funding opportunity was created on Jul 28, 2020.
  • Applicants must submit their applications by Aug 27, 2020 No Explanation. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $1,250,000.00 in funding.
  • The number of recipients for this funding is limited to 2 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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